A conserved human germline V kappa gene directly encodes rheumatoid factor light chains
نویسندگان
چکیده
The full-length gene that encodes the light chain variable regions of an idiotypically related group of human IgM kappa rheumatoid factors (RFs) has been cloned and sequenced. The deduced amino acid sequence is identical to four separate RF proteins. These results prove that genes capable of encoding human anti-IgG autoantibody light chains without any somatic mutation are present in the kappa gene repertoire of normal people.
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of monoclonal human IgRF autoantibodies. J Exp Med 1984;160:893-904. 44. Fong S, Chen PP, Gilbertson JA, el al. Expression of three cross reactive idiotypes on rheumatoid factor autoantibodies from patients with autoimmune diseases and seropositive adults. J Immunol 1986;137: 122-8. 45. Chen PP, Albrandt K, Orida NK, etal. Genetic basis for the cross-reactive idiotypes on the light chains of hu...
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 164 شماره
صفحات -
تاریخ انتشار 1986